Bio-Pharmaceutical Services
ADVENT provides a wide array of services supporting the entire phase of the product lifecycle - from conceptual design through production. Our innovative consulting services cover process development and qualification, process equipment design commissioning and qualification, and GMP facility design, commissioning, and qualification.

Energy Sector Services
ADVENT offers a wide array of design/analysis from structural analysis and code compliance to fluid/flow simulation and heat transfer systems. ADVENT holds a number of patents for our innovative designs for nuclear reactor vessel head components. ADVENT principals have more than 100 years of combined experience in structural engineering, mechanical design, and plant shutdown support. ADVENT has been recognized by Department of Energy prime contractors Westinghouse Idaho Nuclear Company, winning the Total Quality Supplier Award.

 Our Services

More than in any other business, the quality of a consulting firm is dependent on qualifications of its professional staff. ADVENT's professional staff is primarily comprised of Engineers from various disciplines (Civil, Mechanical, Chemical, and Electrical).

Most of our Engineers are Process Engineers, many of whom possess professional licenses or advanced degrees. Our engineering base allows for a competent staff with the ability to add value to any project; whether it involves process development, engineering, qualification, or regulatory compliance.

Several of ADVENT key personnel hold responsible positions on industry code committees. ADVENT personnel have published/presented over 30 technical papers in journals and industry-wide forums.

Biotechnology Related Pharmaceutical Presentation & Publications
 ACS National Meetings
 AICHE Annual Meetings
 CASSS Annual Meeting
 Biotechnology Progress
 Chemical Engineering Journal
 Chemical Engineering Science
 Electrophoresis Expression
 IBC's 6th International Biopharmaceutical Manufacturing and Development (BMD) Summit
 Protein and Purification
 ASCE Engineering Mechanics Specialty Conference
 ASME Pressure Vessel and Piping Conference
 International Journal for Numerical and Analytical Methods in Geomechanics
 International Journal of Heat and Mass Transfer
 Proceedings of the International Conference on Computational Engineering Science

Novel Approaches in Engineering, Commissioning, & Validation for Biotechnology
 Integrating Risk Assessment into Validation Planning
 Practical Risk Assessment Techniques for API Processes
 System Suitability in the Quality Assessment of Cell-Based Bioassay
 Approach to Equipment Validation for Clinical Manufacturing
 Reverse Engineering: A First-to-Market Means to Compliance
 Application of Risk Assessment to Minimizing Qualification Costs for Temperature controlled Chambers
 Cleaning Validation in Contract cGMP API Manufacturing: Analytical Optimization
 Statistical Analyses in Pharmaceutics and Biotechnology
 Thermocouples: Fundamentals and Validation Issues
 Chromatography Column Packing Studies
 Antibody Purification: Affinity Chromatography and Other Techniques
 Overview of Analytical methods for Biotechnological and Pharmaceutical Industries

Downstream process development roadmap for non MAb target protein - Case Study
Dr. Abhijit Banerjee and Dr. Nishant Bhatia
Abstract: For downstream process development a roadmap for scale up for a recombinant target protein with emphasis on the use of in-line dilution, disposables, and real time chromatographic data analysis has been developed and used in clinical production. Based on preliminary process descriptions, PFDs, P&IDs, material balances, operability analyses, and QbD results the roadmap develops the minimum step unit operations desirable.